Guanidino compounds

267n2967n67n 123 21010Compounds having the general structure II are provided: A is selected from the group consisting of C or CH and X and Y are independently selected from the group consisting of CH, N, C═O, C═S, (CRR), S═O, SO, O, NR, S, C(═O)-(CRR), and C(═S)-(CRR)where n is 1, 2, or 3. W is selected from the group consisting of and Z, Z, and Zare independently selected from the group consisting of substituted carbon and nitrogen. L is selected from the group consisting of N, O, S, S═O, SO, C(O), NC(O), NC(S), OC(O), OC(S), C(NR), C(NOR), and a covalent bond. Compounds of formula II are agonists of the melanocortin-4 receptor ("MC4-R") and therefore may have useful properties for controlling diseases related to MC4-R action in humans, such as obesity and type II diabetes.