Methods for designing agents that interact with MMP-13

Methods for designing agents that interact with MMP-13

The present invention relates to the three dimensional structure of human collagenase 3 (MMP-13), as well as to (i) methods of using the MMP-13 structure to rationally design or identify compounds or molecules that inhibit or activate MMP-13 activity, and (ii) compounds identified using said methods...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Chen, James M, Mobilio, Dominick, Moy, Franklin J, Parris, Kevin D, Powers, Robert, Bao Xu, Zhang
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The present invention relates to the three dimensional structure of human collagenase 3 (MMP-13), as well as to (i) methods of using the MMP-13 structure to rationally design or identify compounds or molecules that inhibit or activate MMP-13 activity, and (ii) compounds identified using said methods.