Bradykinin B1 receptor antagonists

1 Bradykinin B-receptor antagonists of formula are disclosed. The compounds are useful for treating diseases associated with inappropriate bradykinin receptor activity, such as diabetic vasculopathy, inflammation, pain, hyperalgesia, asthma, rhinitis, septic shock, atherosclerosis and multiple scler...

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Hauptverfasser: Ohlmeyer, Michael H. J, Baldwin, John J, Dolle, III, Roland E, Paradkar, Vidyadhar, Quintero, Jorge Gabriel, Pan, Gonghua
Format: Patent
Sprache:eng
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Zusammenfassung:1 Bradykinin B-receptor antagonists of formula are disclosed. The compounds are useful for treating diseases associated with inappropriate bradykinin receptor activity, such as diabetic vasculopathy, inflammation, pain, hyperalgesia, asthma, rhinitis, septic shock, atherosclerosis and multiple sclerosis. Pyrimidines, triazines, and anilines in which Q is imidazolyl or pyrrolyl are particularly preferred.