Ret-independent signaling pathway for GDNF

Ret-independent signaling pathway for GDNF

2+i Methods for screening for agonists and antagonists of GPI-anchored independent intracellular signaling resulting in [Ca]elevation, ERK1, ERK2 and CREB phosphorylation, and Src family kinase activation are described, as well as methods for treatment involving administration of agonists/antagonist...

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Hauptverfasser: Titievsky, Alexey Vladimirovich, Poteriaev, Dmitri, Arumäe, Urmas, Saarma, Mart
Format: Patent
Sprache:eng
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Zusammenfassung:2+i Methods for screening for agonists and antagonists of GPI-anchored independent intracellular signaling resulting in [Ca]elevation, ERK1, ERK2 and CREB phosphorylation, and Src family kinase activation are described, as well as methods for treatment involving administration of agonists/antagonists of such signaling.