Non-peptide GnRH agents, pharmaceutical compositions and methods for their use

Non-peptide GnRH agents capable of inhibiting the effect of gonadotropin-releasing hormone are described. Such compounds and their pharmaceutically acceptable salts, prodrugs, and active metabolites are suitable for treating mammalian reproductive disorders and steroid hormone-dependent tumors as we...

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Hauptverfasser: Anderson, Mark B, Christie, Lance Christopher, Do, Quyen-Quyen Thuy, Feng, Jun, Hong, Yufeng, Li, Haitao, Pathak, Ved P, Rajapakse, Ranjan Jagath, Sun, Eric T, Tompkins, Eileen Valenzuela
Format: Patent
Sprache:eng
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Zusammenfassung:Non-peptide GnRH agents capable of inhibiting the effect of gonadotropin-releasing hormone are described. Such compounds and their pharmaceutically acceptable salts, prodrugs, and active metabolites are suitable for treating mammalian reproductive disorders and steroid hormone-dependent tumors as well as for regulating fertility, where suppression of gonadotropin release is indicated. Methods for synthesizing the compounds and intermediates useful in their preparation are also described.