Therapeutic treatment and prevention of infections with a bioactive material(s) encapuslated within a biodegradable-bio-compatable polymeric matrix

Therapeutic treatment and prevention of infections with a bioactive material(s) encapuslated within a biodegradable-bio-compatable polymeric matrix

Novel burst-free, sustained release biocompatible and biodegrable microcapsules which can be programmed to release their active core for variable durations ranging from 1-100 days in an aqueous physiological environment. The microcapsules are comprised of a core of polypeptide or other biologically...

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Hauptverfasser: Setterstrom, Jean A, Tice, Thomas R, Jacob, Elliot, Reid, Robert H, van Hamont, John, Boedecker, Edgar C, Jeyanthi, Ramassubbu, Friden, Phil, Roberts, F. Donald, McQueen, Charles E, Bhattacharjee, Apurba, Cross, Alan, Sadoff, Jerald, Zollinger, Wendell
Format: Patent
Sprache:eng
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Zusammenfassung:Novel burst-free, sustained release biocompatible and biodegrable microcapsules which can be programmed to release their active core for variable durations ranging from 1-100 days in an aqueous physiological environment. The microcapsules are comprised of a core of polypeptide or other biologically active agent encapsulated in a matrix of poly(lactide/glycolide) copolymer having a molar composition of lactide/glycolide from 90/10 to 40/60, which may contain a pharmaceutically-acceptable adjuvant, as a blend of uncapped free carboxyl end group and end-capped forms ranging to ratios from 100/0 to 1/99.