Nucleic acids encoding interleukin-1 inhibitors and processes for preparing interleukin-1 inhibitors

Nucleic acids encoding interleukin-1 inhibitors and processes for preparing interleukin-1 inhibitors

121 2 1 2 1 2 Compounds are disclosed having the general formula R-X-R, wherein Rand Rare biologically active groups, at least one of which is polypeptidic. X is a non-peptidic polymeric group. Rand Rmay be the same or different. Preferred Rand Rgroups are interleukin-1 receptor antagonist, 30 kDa T...

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Hauptverfasser: Thompson, Robert C, Hannum, Charles H, Eisenberg, Stephen P, Arend, William P, Joslin, Fenneke G, Sommer, Andreas
Format: Patent
Sprache:eng
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Zusammenfassung:121 2 1 2 1 2 Compounds are disclosed having the general formula R-X-R, wherein Rand Rare biologically active groups, at least one of which is polypeptidic. X is a non-peptidic polymeric group. Rand Rmay be the same or different. Preferred Rand Rgroups are interleukin-1 receptor antagonist, 30 kDa TNF inhibitor, interleukin-2 receptors and CR1 and muteins thereof. Also included are site selectively modified interleukin-1 receptor antagonist and 30 kDa TNF inhibitor.