Heterocycles useful in the treatment of benign prostatic hyperplasia

a This invention relates a to a series of heterocyclic substituted piperazines of Formula I pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the invention selectively inhibit binding to the α-adrenergic receptor, a receptor which has been impl...

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Bibliographische Detailangaben
Hauptverfasser: Hutchings, Richard H, Khatuya, Haripada, Kuo, Gee-Hong, Li, Xiaobing, Murray, William V, Prouty, Catherine, Villani, Frank, Yim, Nelson C. F, Maryanoff, Cynthia
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:a This invention relates a to a series of heterocyclic substituted piperazines of Formula I pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the invention selectively inhibit binding to the α-adrenergic receptor, a receptor which has been implicated in benign prostatic hyperplasia. As such the compounds are potentially useful in the treatment of this disease.