7-Substituted quinazolin-2,4-diones useful as antibacterial agents

7-Substituted quinazolin-2,4-diones useful as antibacterial agents

Antibiotic resistance is a worldwide problem ( ., 1996;39:3853) with catastrophic potential ( ., 1995;88:797). In 1995, the American Society of Microbiology Task Force issued a report defining the resistance problem and calling for new antibacterial agents with novel structures or mechanisms to offe...

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Hauptverfasser: Domagala, John Michael, Ellsworth, Edmund Lee, Huang, Liren, Renau, Thomas Eric, Singh, Rajeshwar, Stier, Michael Andrew
Format: Patent
Sprache:eng
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Zusammenfassung:Antibiotic resistance is a worldwide problem ( ., 1996;39:3853) with catastrophic potential ( ., 1995;88:797). In 1995, the American Society of Microbiology Task Force issued a report defining the resistance problem and calling for new antibacterial agents with novel structures or mechanisms to offer alternatives to existing therapeutic choices. The invention is a series of 7-substituted quinazolin-2,4-diones useful as antibacterial agents, processes for the preparation of the compounds, and a pharmaceutical composition containing one or more of the compounds.