Acetylenic -amino acid-based sulfonamide hydroxamic acid tace inhibitors

Acetylenic -amino acid-based sulfonamide hydroxamic acid tace inhibitors

This invention relates to acetylenic aryl sulfonamide hydroxamic acids which act as inhibitors of TNF- converting enzyme (TACE). The compounds of the present invention are useful in disease conditions mediated by TNF- , such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis,...

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Hauptverfasser: Levin, Jeremy I, Chen, James M, Cole, Derek C, Du, Mila T, Laakso, Leif M
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creator Levin, Jeremy I
Chen, James M
Cole, Derek C
Du, Mila T
Laakso, Leif M
description This invention relates to acetylenic aryl sulfonamide hydroxamic acids which act as inhibitors of TNF- converting enzyme (TACE). The compounds of the present invention are useful in disease conditions mediated by TNF- , such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative cartilage loss. Compounds of the formula: are useful in treating disease conditions mediated by TNF- , such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative cartilage loss.
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title Acetylenic -amino acid-based sulfonamide hydroxamic acid tace inhibitors
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