Acetylenic -amino acid-based sulfonamide hydroxamic acid tace inhibitors
This invention relates to acetylenic aryl sulfonamide hydroxamic acids which act as inhibitors of TNF- converting enzyme (TACE). The compounds of the present invention are useful in disease conditions mediated by TNF- , such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis,...
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| Format: | Patent |
| Sprache: | eng |
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| Zusammenfassung: | This invention relates to acetylenic aryl sulfonamide hydroxamic acids which act as inhibitors of TNF- converting enzyme (TACE). The compounds of the present invention are useful in disease conditions mediated by TNF- , such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative cartilage loss.
Compounds of the formula: are useful in treating disease conditions mediated by TNF- , such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative cartilage loss. |
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