Process for the isolation and purification of mevinolin

This invention relates to a process for the isolation and purification of mevinolin from fermentation liquor. In a process for preparing mevinolin by fermentation of a biomass in a fermentation liquor, which includes dissolving mevinolin from the biomass into the fermentation liquor, and separating...

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Bibliographische Detailangaben
Hauptverfasser:	Kéri, Vilmos, Högye, Irma, Jekkel, Antónia, Bagdi, Ilona, Ambrus, Gábor, Jakab, Attila, Andor, Attila, Deák, Lajos, Szabó , István, Bálint, János, Scheidl, Zsuzsanna, Deli, Etelka, Horváth, Gyula, Szabó, Csaba, Láng, Ildikó, Székely, Imre, Moravcsik, Imre, Kovács, Vera, Mátyás, Szabolcs, Sztáray, Zsuzsanna, Eszenyi, László, Ilköy, Éva
Format:	Patent
Sprache:	eng
Online-Zugang:	Volltext bestellen
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Beschreibung
Zusammenfassung:	This invention relates to a process for the isolation and purification of mevinolin from fermentation liquor. In a process for preparing mevinolin by fermentation of a biomass in a fermentation liquor, which includes dissolving mevinolin from the biomass into the fermentation liquor, and separating the biomass from the fermentation liquor to obtain a separated fermentation liquor, separating the mevinolin from the separated fermentation liquor, and recovering the end product, the improvement which comprises carrying out the dissolving at a pH between 7.5 and about 10, and the separating of the mevinolin is carried out at a pH between about 4.5 and about 1.