Substituted indoles, pharmaceutical compounds containing such indoles and their use as PPAR- binding agents

Substituted indoles, pharmaceutical compounds containing such indoles and their use as PPAR- binding agents

The invention relates to substituted indoles, pharmaceutical compositions containing such indoles, and their use in treating or preventing diseases or conditions mediated by the Peroxisome Proliferator Activated Receptor- (PPAR- ). Disclosed are substituted indoles, pharmaceutical compositions conta...

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Bibliographische Detailangaben
Hauptverfasser: Stolle, Andreas, Dumas, Jacques P, Carley, William, Coish, Philip D. G, Magnuson, Steven R, Wang, Yamin, Nagarathnam, Dhanapalan, Lowe, Derek B, Su, Ning, Bullock, William H, Campbell, Ann-Marie, Qi, Ning, Baryza, Jeremy L, Cook, James H
Format: Patent
Sprache:eng
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Zusammenfassung:The invention relates to substituted indoles, pharmaceutical compositions containing such indoles, and their use in treating or preventing diseases or conditions mediated by the Peroxisome Proliferator Activated Receptor- (PPAR- ). Disclosed are substituted indoles, pharmaceutical compositions containing such indoles, and their use in treating or preventing PPAR- mediated diseases or conditions, such as osteopenia, osteoporosis, cancer, diabetes and atherosclerosis.