Compositions providing for increased IGF-I solubility

The present invention relates generally to pharmaceutical compositions. More particularly, the invention relates to IGF-I compositions that provide high concentrations of soluble IGF-I at desirable pHs. Novel IGF-I compositions are described. The compositions include a solubilizing compound comprisi...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Shirley, Bret A, Bajwa, Kamaljit
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The present invention relates generally to pharmaceutical compositions. More particularly, the invention relates to IGF-I compositions that provide high concentrations of soluble IGF-I at desirable pHs. Novel IGF-I compositions are described. The compositions include a solubilizing compound comprising a guanidinium group that provides for IGF-I compositions in which IGF-I is highly soluble at pHs of about 5.5 or greater and at refrigerated temperatures.