Pyridylthiophene compounds

This invention relates to novel pyridylfuran and pyridylthiophene compounds, their pharmaceutically effective salts, processes for the preparation thereof, the use thereof in treating cytokine mediated diseases and/or cell adhesion molecule mediated diseases, and pharmaceutical compositions for use in such therapy. A compound of the formula: and its pharmaceutically effective salts, wherein Rand Rare independently selected from the following:(a) hydrogen, halo, R-, Calkenyl, Calkynyl, hydroxy-R-, R-O-R-, or the like; (b) Ar-, Ar-R-, Ar-Calkenyl, Ar-Calkynyl, Ar-O-, Ar-O-R- or the like; (c) R-C(O)-, -NO, cyano, NH-C(O)-, R-NH-C(O)-, (R)-N-C(O)-, Ar-C(O)- or the like; and (d) R-C(O)-NH-, Ar-C(O)-NH- or the like; wherein Ar is optionally substituted aryl or heteroaryl such as phenyl and pyridyl; and wherein Ris optionally halo-substituted Calkyl; Ris selected from the following: (e) cyano, formyl, tetrazolyl, triazolyl, imidazolyl, oxazolyl, thiazolyl, R-C(O)-, Calkenyl-C(O)-, Calkynyl-C(O)-, R-C(O)-R-, or the like; (f) R-C(O)-NH-, Ar-C(O)-NH-, or the like; (g) R-S-, R-S(O)-, R-NH-S(O)-, or the like; and (h) Ar-C(O)-, Ar-R-C(O)-, Ar-Calkenylene-C(O)- or the like; or two of R, Rand Rtogether form a group of the formula -A-B-A- or -A-B-A-B-A- such as cyclic alkyl optionally substitued with oxo; Ris hydrogen, halo, R-C(O)- and the like; X is O, S, S(O) or S(O); m is 0, 1, 2, 3 or 4. The present invention also provides processes for the preparation thereof, the use thereof in treating cytokine mediated diseases and/or cell adhesion molecule (CAM) mediated diseases and pharmaceutical compositions for use in such therapy.