5-lipoxygenase inhibitors: (2-azinylamino) quinone derivatives

This invention pertains to a series of new derivatives of (2-azinylamino) quinone, their synthesis, and the use of these derivatives as 5-lipoxygnease inhibitors. We have synthesized a series of new derivatives of (2-azinylamino) quinone, that have the general formula shown below. Several compounds of this new series of derivatives have been shown to be inhibitors of 5-lipoxygenase, with minimal or no effect on cycloxygenase-1 and 2-(COX-1 and COX-2) activity. where:A is N, CH, or, CCl;B is N, CH, CCH, or Cph;X is H, Cl, Br, or I;Y is H, or CH;Ris H, CH, OCH, or Ph; and Ris H, CH, OCH, or Ph; or R-Ris (CH CH); andRis H or CH.