Synthesis, deprotection, analysis and purification of RNA and ribozymes

Synthesis, deprotection, analysis and purification of RNA and ribozymes

This invention relates to the synthesis, deprotection, and purification of enzymatic RNA or modified enzymatic RNA molecules in milligram to kilogram quantities with high biological activity. Provided is a method for purification and synthesis of RNA molecules that have at least one chemical modific...

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Bibliographische Detailangaben
Hauptverfasser: Usman, Nassim, Wincott, Francine, Sweedler, David, Beigelman, Leonid, Dudycz, Lech W, Grimm, Susan, DiRenzo, Anthony, Tracz, Danuta
Format: Patent
Sprache:eng
Online-Zugang:Volltext bestellen
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Beschreibung
Zusammenfassung:This invention relates to the synthesis, deprotection, and purification of enzymatic RNA or modified enzymatic RNA molecules in milligram to kilogram quantities with high biological activity. Provided is a method for purification and synthesis of RNA molecules that have at least one chemical modification.