Snail, new tumoral progression marker and target protein of new antitumoral compounds

Snail, new tumoral progression marker and target protein of new antitumoral compounds

This is a 371 of PCT/ES00/00226 filed Jun. 27, 2000. The Snail transcription factor has been identified as a repressor of the expression of E-cadherin. The expression of Snail induces invasive and metastatic capacity in tumor cells. This invention presents: a new target protein, Snail, for the ident...

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Hauptverfasser: Cano García, Amparo, Nieto Toledano, Ma Angela, Rodrigo Castro, Ma Isabel, Locascio, Annamaria, García del Barrio, Marta, de Valderrama, María José Blanco Fernandez, Portillo Pérez, Francisco, Pérez Moreno, Mirna Alicia
Format: Patent
Sprache:eng
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Zusammenfassung:This is a 371 of PCT/ES00/00226 filed Jun. 27, 2000. The Snail transcription factor has been identified as a repressor of the expression of E-cadherin. The expression of Snail induces invasive and metastatic capacity in tumor cells. This invention presents: a new target protein, Snail, for the identification of new antitumoral compounds and a new diagnostic tumor marker, indicative of tissue invasion and metastatic capacity.