Mirror-symmetrical selection and evolution of nucleic acids

The present invention relates to methods for identifying and producing L-nucleic acids that interact with a target molecule having a natural configuration, as well as to the L-nucleic acids produced by means of this method. Furthermore, the invention relates to the use of the D-nucleic acids binding to the optical antipode of the target molecule as a matrix for producing L-nucleic acids with an identical sequence, as well as to pharmaceutical compositions, kits, diagnostic agents and sensor systems containing the L-nucleic acids of the invention. A method is disclosed for identifying and producing L-nucleic acids which interact with a target molecule having a natural configuration, as well as the L-nucleic acids produced by this method. Also disclosed is the use of D-nucleic acids which bind to the optical antipode of the target molecule as a matrix for producing L-nucleic acids with an identical sequence, and pharmaceutical compositions and kits which contain the disclosed L-nucleic acids.