Phthalazine derivatives as phosphodiesterase 4 inhibitors

Phthalazine derivatives as phosphodiesterase 4 inhibitors

This is a 371 of International Application Serial No. PCT/EP98/08291, filed Dec. 17, 1998. Compounds of formula (I) wherein B is alkylene, amino, CONH or a bond; Cy is optionally substituted phenyl or heteroaryl; R is H, phenyl or (C)alkyl optionally substituted; Ris (C)alkyl or polyfluoro(C)-alkyl;...

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Hauptverfasser: Napoletano, Mauro, Norcini, Gabriele, Botta, Daniela, Grancini, Giancarlo, Morazzoni, Gabriele, Santangelo, Francesco, Siro Herrero, Jorge G, Garcia Navaio, José Luis, Alvarez-Builla, Julio G
Format: Patent
Sprache:eng
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Zusammenfassung:This is a 371 of International Application Serial No. PCT/EP98/08291, filed Dec. 17, 1998. Compounds of formula (I) wherein B is alkylene, amino, CONH or a bond; Cy is optionally substituted phenyl or heteroaryl; R is H, phenyl or (C)alkyl optionally substituted; Ris (C)alkyl or polyfluoro(C)-alkyl; Ris (C)cycloalkyl optionally containing an oxygen atom and optionally substituted; and the N→O derivatives and pharmaceutically acceptable salt thereof are PDE 4 and TNF inhibitors.