Anti-inflammatory indole derivatives

This application is a 371 of PCT/GB00/00275 Jan. 31, 2000 now WO 00/46198. Compounds of formula (I) or a pharmaceutically acceptable salt, in vivo hydrolysable ester, or an N-Calkyl or N,N-di-(Calkyl)amide thereof, where X is CHor SO; Ris an aryl optionally substituted by alkyl, alkenyl, alkynyl, halo, haloalkyl including perhaloalkyl such as trifluoromethyl, mercapto, alkoxy, haloalkoxy, alkenyloxy, alkynyloxy, hydroxyalkoxy, alkoxyalkoxy, alkanoyl, alkanoyloxy, cyano, nitro, amino, mono- or di-alkyl amino, oximino, sulphonamido, carbamoyl, mono or dialkylcarbamoyl or S(O)Rwhere m is defined above and Ris hydrocarbyl; Ris a group ORor S(O)R, where q is 0, 1 or 2 and Ris a hydrogen-containing alkyl group substituted by at least one functional group as defined below, or an aryl group which is optionally substituted by one or more functional groups as defined below; and R2, R3, R5, R6 and R7 are specified organic groups. These compounds are useful in therapy, in particular of inflammatory disease, and methods of producing them as well as pharmaceutical compositions containing them are also described and claimed.