3-thioxo-[1,2,4]-oxadiazinan-5-one derivatives

This invention is directed to anti-atherosclerotic agents and more specifically, to compounds, compositions and methods for treating atherosclerotic conditions, such as dyslipoproteinemias and coronary heart disease. This invention specifically relates to 3-thioxo-[1,2,4]-oxadiazinan-5-one derivatives that elevate HDL cholesterol concentration, and which may be useful for the treatment of atherosclerotic conditions such as coronary heart disease. whereinR is alkyl, alkenyl, or alkynyl;Rand Rare each independently hydrogen alkyl, or aryl; andAr is phenyl, indanyl, benzhydryl, or phenyl, substituted with one or more groups selected from the group consisting of halogen, alkyl, perfluoroalkyl, lower alkoxy, perfluoroalkylalkoxy, dialkylamino, and aroyloxy.