Acridone-derived compounds useful as antineoplastic and antiretroviral agents

The present invention relates to acridone-derived compounds which are bisimidazoacridones, bistriazoloacridones and hybrid molecules having both imidazoacridone and triazoloacridone moieties. These compounds are useful as anti-neoplastic and anti-retroviral agents. The present invention relates to s...

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Hauptverfasser: Michejda, Christopher J, Cholody, Marek W, Rice, William G, Turpin, James A
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The present invention relates to acridone-derived compounds which are bisimidazoacridones, bistriazoloacridones and hybrid molecules having both imidazoacridone and triazoloacridone moieties. These compounds are useful as anti-neoplastic and anti-retroviral agents. The present invention relates to several novel acridone-derived compounds of of formula (I) or (II). These compounds are potent anti-viral agents, useful in the treatment of viral diseases, such as Human Immunodeficiency Virus. In addition, these compounds are anti-neoplastic agents useful in the treatment of various forms of cancer. wherein R1 and R2 are independently -H, -OH, amino, alkylamino, dialkylamino, alkoxy, alkyl, haloalkyl or halogen; n is 2 to 6, X and X′ are independently -N or -NO; Y and Y′ are independently -N or -CH, or -H; and the double-slash represents a double bond or no bond.