Sustained release non-steroidal, anti-inflammatory and lidocaine PLGA microspheres

This invention relates to providing novel pharmaceutical compositions for local delivery and sustained release of non-steroidal, anti-inflammatory drugs (NSAIDS) from biocompatible, biodegradable poly(DL-lactide-co-glycolide) (PLGA) microspheres. The resulting product is applied locally into soft tissues surrounding a surgical incision or traumatic wound site where it will locally sustain release of the NSAID. A controlled release microcapsule pharmaceutical formulation for burst-free, sustained, programmable release of a non-steroidal, antiinflammatory drug over a duration from 24 hours to 2 months, comprising: a non-steroidal, antiinflammatory drug and a blend of biocompatible, biodegradable poly (lactide/glycolide).