Method for obtaining polymorph a from doxazosine mesylate
This invention relates to a process for the preparation of the polymorph A of doxazosin mesylate. This polymorph is crystalline and is named Form A. The invention discloses a process for the preparation of the polymorh A of doxazosin meylate, consisting essentially of reacting doxazosin base with me...
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| Format: | Patent |
| Sprache: | eng |
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| Zusammenfassung: | This invention relates to a process for the preparation of the polymorph A of doxazosin mesylate. This polymorph is crystalline and is named Form A.
The invention discloses a process for the preparation of the polymorh A of doxazosin meylate, consisting essentially of reacting doxazosin base with methanesulfonic acid in a mixture of solvents containing an alcohol and a chlorinated solvent, subsequently removing the chlorinated solvent by distillation and precipitating the desired product in an alcohol, after heating the suspension formed to the reflux temperature of the solvent. |
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