(4-oxo-2-pyrimidinyl)thioalkyl compounds useful as AICARFT inhibitors

The present invention relates to compounds that inhibit the enzyme aminoimidazole carboxamide ribonucleotide formyl transferase (AICARFT), to pharmaceutical compositions containing these compounds, and to their use to inhibit AICARFT. The-invention also relates to the preparation of these compounds, and to intermediates for preparing these compounds. Compounds of the formula: (where R, Rand Rare defined in the specification) are inhibitors of AICARFT. These compounds, as well as their pharmaceutically acceptable salts, solvents, prodrugs, and pharmaceutically active metabolites, are useful in pharmaceutical compositions for treating diseases such as cancer.