Formulated nucleic acid compositions and methods of administering the same for gene therapy

The following information is presented solely to assist the understanding of the reader, none of the information is admitted to describe prior art to the claims of the present invention. Compositions and methods for administering nucleic acid compositions in vitro to cells in culture or in vivo to an organism whereby the uptake of nucleic acids is enhanced are provided. Various compositions, including those incorporating protective, interactive, non-condensing compounds, are utilized to protect and administered nucleic acid formulation, thereby prolonging the localized bioavailability of the administered nucleic acid and enhancing expression from the nucleic acid.