Use of a 2-hydroxy-4-trifluoromethylbenzoic acid derivatives as inhibitors of the activation of the nuclear transcription factor NF- B

The present invention relates to inhibitors of the nuclear transcription factor kappaB (NF- B) and to their use in therapy. Specifically, the present invention relates to the use of 2-hydroxy-4-trifluoromethylbenzoic acid derivatives to inhibit the activation of the transcription factor NF- B. A method for inhibiting the activation of transcription factor NF- B in a warm-blooded animal in need thereof, comprises administering to said animal an effective amount of a compound of formula I wherein R represents hydrogen or COCH, or a pharmaceutically acceptable salt or a prodrug thereof.