Sonodynamic therapy using an ultrasound sensitizer compound

This invention relates to the use of ultrasound-susceptibility modification agents, e.g. water-soluble polymers such as polyalkylene oxides and derivatives thereof, surfactants, oil-in-water emulsions, stabilized particles and certain chromophoric groups such as sulfonated dyes, in methods of treatment of the human or animal body by sonodynamic therapy. A method of treatment of a human or animal body by sonodynamic therapy in which a sensitizer agent is administered to the body and the body is exposed to ultrasound to achieve a cytopathogenic effect at a site therein, wherein the said sensitizer agent is a physiologically tolerable substance which is capable of enhancing the cytopathogenic efficacy of said sonodynamic therapy. Preferably, the sensitizer agent is a water-soluble polymer compound or a conjugate thereof.