Compositions for treating viral infections, and methods therefor

The present invention relates generally to the fields of medicine and virology. More particularly, it concerns methods and combination compositions for the treatment of viral infections, especially retroviral infections, for treatment of individuals who are treatment experienced and resistant to current protocols, and for post-exposure prophylaxis. Methods and combinations of an agent that promotes DNA synthesis in a virally-targeted cell and a nucleoside analogue having antiviral activity are provided for treating a viral infection in a subject in need thereof. Such compositions are particularly effective where the subject has resistance to a nucleoside analogue, where the subject has resting cellular reservoirs of such a virus, or to induce a post-treatment period of replication incompetence of such a virus.