Peroral dosage form for peptide containing medicaments, in particular insulin

The invention concerns a peroral application form for peptide pharmaceuticals, wherein at least one peptide pharmaceutical is distributed in a matrix of gelatin or a gelatin derivative together with pharmaceutically conventional carriers and inactive ingredients. The invention further concerns a pro...

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Bibliographische Detailangaben
Hauptverfasser: Wunderlich, Jens-Christian, Schick, Ursula, Freidenreich, Jurgen, Werry, Jurgen
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The invention concerns a peroral application form for peptide pharmaceuticals, wherein at least one peptide pharmaceutical is distributed in a matrix of gelatin or a gelatin derivative together with pharmaceutically conventional carriers and inactive ingredients. The invention further concerns a process for the preparation of such peroral dosage forms. There is provided a plural dosage form for peptide pharmaceuticals comprising a matrix of gelatin or gelatin derivative having distributed therein the peptide pharmaceutical in particular insulin, as well as, pharmaceutically conventional carriers and additives. By selection of the appropriate gelatin the pharmaceutical is liberated in the small intestine or the large intestine so that is not enzymatically degraded anymore by peptidases.