Lavendamycin analogs, quinoline-5,8-diones and methods of using them
Lavendamycin (A) was isolated from the fermentation broth of by Doyle and co-workers. See Doyle et al., 22, 4595 (1981) and Gould et al., 41, 77 (1982). Lavendamycin has broad spectrum antitumor, antibacterial and antiviral activity. See, e.g., Shibata et al., 33, 1231 (1980); Balitz et al., 35, 259...
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| Sprache: | eng |
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| Zusammenfassung: | Lavendamycin (A) was isolated from the fermentation broth of
by Doyle and co-workers. See Doyle et al.,
22, 4595 (1981) and Gould et al.,
41, 77 (1982). Lavendamycin has broad spectrum antitumor, antibacterial and antiviral activity. See, e.g., Shibata et al.,
33, 1231 (1980); Balitz et al.,
35, 259 (1982); Boger et al.,
30, 1918 (1987).
The invention provides novel lavendamycin analogs having the following general formula: and quinoline-5,8-diones having the following formula: Methods of making and using and compositions containing these compounds are also disclosed. |
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