Local anesthetic compounds

1. Field of the Invention This invention is directed to novel local anesthetic compounds, pharmaceutical compositions containing these compounds, methods of use and methods of preparing these compounds. In one embodiment, the compounds are of the following formula: wherein: Rand Rare independently s...

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Hauptverfasser: Axt, Sabine M, Church, Timothy J, Jacobsen, John R, Jenkins, Thomas E, Ji, Yu-Hua, Wu, Huiwei
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:1. Field of the Invention This invention is directed to novel local anesthetic compounds, pharmaceutical compositions containing these compounds, methods of use and methods of preparing these compounds. In one embodiment, the compounds are of the following formula: wherein: Rand Rare independently selected from the group consisting of hydrogen, alkyl, halo, cyano, hydroxy, alkoxy, amino, monosubstituted or disubstituted amino, carboxy, and alkoxycarbonyl; Rand Rare independently selected from the group consisting of hydrogen and alkyl; Ris alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycle, or substituted heterocycle; Rand Rare independently selected from the group consisting of hydrogen, alkyl, substituted alkyl and NRaRb-where Ra and Rb are alkyl; and Ar is selected from the group consisting of aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycle, substituted heterocycle, cycloalkyl and substituted cycloalkyl; or a pharmaceutically acceptable salt thereof. The compounds find use as local anesthetics.