Ribozyme treatment of diseases or conditions related to levels of intercellular adhesion molecule-1 (CAM-1)

The present invention relates to therapeutic compositions and methods for the treatment or diagnosis of diseases or conditions related to ICAM-1 levels, such as transplant rejection, cancer, rheumatoid arthritis, asthma, reperfusion injury, and inflammatory or autoimmune disorders. For example, such...

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Bibliographische Detailangaben
Hauptverfasser: Grimm, Susan, Stinchcomb, Dan T, McSwiggen, James, Sullivan, Sean, Draper, Kenneth G
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The present invention relates to therapeutic compositions and methods for the treatment or diagnosis of diseases or conditions related to ICAM-1 levels, such as transplant rejection, cancer, rheumatoid arthritis, asthma, reperfusion injury, and inflammatory or autoimmune disorders. For example, such treatments will be useful for transplant rejection, myocardial ischemia, stroke, psoriasis, and Kawasaki disease. The present invention relates to enzymatic RNA molecules which cleave ICAM-1 mRNA.