Methods for the production of gelatin and full-length triple helical collagen in recombinant cells
The invention relates generally to the field of recombinant protein production, and particularly to the production of telopeptide collagen in recombinant host cells. Methods are disclosed for simplified recombinant production of fibrillar collagens. DNAs encoding fibrillar collagen monomers lacking...
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| Format: | Patent |
| Sprache: | eng |
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| Zusammenfassung: | The invention relates generally to the field of recombinant protein production, and particularly to the production of telopeptide collagen in recombinant host cells.
Methods are disclosed for simplified recombinant production of fibrillar collagens. DNAs encoding fibrillar collagen monomers lacking the N propeptide, the C propeptide, or both propeptides are introduced into recombinant host cells and expressed. Trimeric collagen is recovered from the recombinant host cells. |
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