Vaccine adjuvant and vaccine method

The present invention comprises methods for synthesizing novel high molecular weight nonionic copolymers. The present invention also comprises high molecular weight nonionic copolymers that are useful as surfactants and have desirable effects on living cells and organisms, including use as adjuvants...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Balasubramanian, Mannarsamy, Newman, Mark Joseph, Emanuele, R. Martin, Rivera-Marrero, Carlos A, Todd, Charles William, Brey, III, Robert Newton
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The present invention comprises methods for synthesizing novel high molecular weight nonionic copolymers. The present invention also comprises high molecular weight nonionic copolymers that are useful as surfactants and have desirable effects on living cells and organisms, including use as adjuvants in vaccines for humans and animals to augment or otherwise modify vaccine induced immune responses. The present invention includes novel polyoxyethylene/polyoxypropylene block copolymers as well as methods for making the block copolymers. The block copolymers are high molecular weight molecules and are useful as general surfactants and display enhanced biological efficacy as vaccine adjuvants.