Submucosa extracts

This invention relates to a bioactive extract or concentrate prepared from basement membranes of natural tissues and the use of those extracts to promote cell growth and proliferation. More particularly, this invention is directed to submucosal tissue extracts and their preparation and use in promot...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Badylak, Stephen F, Brightman, Andrew O, Hodde, Jason P, McPherson, Timothy B, Voytik-Harbin, Sherry L
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:This invention relates to a bioactive extract or concentrate prepared from basement membranes of natural tissues and the use of those extracts to promote cell growth and proliferation. More particularly, this invention is directed to submucosal tissue extracts and their preparation and use in promoting cell growth in vitro and in vivo. A method for preparing a bioactive extract from warm-blooded vertebrate submucosal tissue is described. The submucosal tissue is extracted using an aqueous solution of extraction excipients, and the extracted bioactive components are then separated from the extraction excipients to provide an isolated extract enriched in bioactive components. The isolated extract is useful, inter alia, as additive for cell growth media to promote cell growth and proliferation in vitro.