Cyclic urea and cyclic amide derivatives

This invention relates to compounds which are agonists and antagonists of the progesterone receptor, their preparation and utility. This invention provides compounds of the formula: wherein: A, B and D are N or CH, with the proviso that A, B and D can not all be CH; Rand Rare independent substituents selected from H, COR, NRCOR, or optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl, or groups; or Rand Rare fused to form an optionally substituted 3 to 8 membered spirocyclic or heterocyclic ring; Ris H or optionally substituted alkyl, aryl, alkoxy, or aminoalkyl; Ris H, Cto Calkyl, or substituted Cto Calkyl; Ris H, OH, NH, or optionally substituted alkyl, or alkenyl, or COR; Ris H or optionally substituted alkyl, aryl, alkoxy, or aminoalkyl; Ris a substituted benzene ring or a five or six membered ring with 1, 2, or 3 heteroatoms from the group including O, S, SO, SOor NR; Ris H or optionally substituted alkyl, aryl, alkoxy, or aminoalkyl; Ris H, alkyl, or substituted alkyl; Ris H or alkyl; Q is O, S, NR, or CRR; Ris CN, SOCF, or optionally substituted alkyl, cycloalkyl, aryl, or heterocyclic ring; Rand Rare H, NO, CN COR, or optionally substituted alkyl, cycloalkyl, aryl, or heterocyclic; Ris Cto Calkyl; or CRRform a six membered ring of the structure below: W is O or a chemical bond; or a pharmaceutically acceptable salt thereof, as well as their use and pharmaceutical compositions as agonists and antagonists of the progesterone receptor.