Method for identifying or screening agonist and antagonist to PPAR

1. Technical Field A method for identifying or screening an agonist for or antagonist to a peroxisome proliferator activated receptor (PPAR) which comprises allowing a test cell and a substance to be tested to coexist, and detecting a change in a ligand-dependent interaction between the PPAR and a c...

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Hauptverfasser: Taniguchi, Tomoyasu, Mizukami, Junko
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:1. Technical Field A method for identifying or screening an agonist for or antagonist to a peroxisome proliferator activated receptor (PPAR) which comprises allowing a test cell and a substance to be tested to coexist, and detecting a change in a ligand-dependent interaction between the PPAR and a coactivator in the test cells due to the substance to be tested by measuring the expression of a reporter gene as an index.