Isolation of a gene encoding human thyrotropin beta subunit

This invention relates to the human thyroid stimulating hormone Beta chain or subunit (hTSH- ), and the gene producing it. Further, the invention relates to applications of this gene. The gene expressing the beta subunit of human thyroid stimulating hormone has been isolated. The gene has been incorporated into plasmid pBR322. Vectors can be used to transform cells which in turn produce pure beta subunits. The beta subunits can then be combined with the alpha subunit of human glycoprotein hormones to produce pure thyroid stimulating hormone.