Methods of preparing polyurethane adhesives, adhesives produced thereby and medical devices employing the same

The present invention is directed to a process for producing polyurethane adhesives, especially pressure sensitive adhesives utilizing a hydroxy-terminated urethane extended polyether (ester) polyol and a moderate range molecular weight diisocyanate. The resulting adhesives provide excellent adhesive and wear characteristics and are essentially non-cytotoxic making them particularly useful for medical applications such as in ostomy and wound care. A polyurethane adhesive composition preferably having pressure sensitive characteristics that is non-cytotoxic and methods of making the same which is especially useful for medical applications such as ostomy and wound care.