Microsampling apparatus and method for multiple channel high throughout purification

The present invention is directed to sampling apparatus and methods usable in, as an example, sample purification, and more particularly, to microsample device apparatus and methods usable in, as an example, high throughput purification of samples from a chemical library. A microsampling device useable in a multiple channel high throughput purification system for purifying a plurality of samples, preferably four or more samples from a chemical library. One aspect of the invention provides a microsampling device for use in the high throughput fluid system. The microsampling device includes a body with a sample flow inlet, a sample flow outlet, and a sample passageway there between. The sample flow inlet and outlet are positionable for fluid communication with the sample flow path of the fluid system. The body has a carrier flow inlet and a carrier flow outlet positioned before fluid communication with the carrier fluid flow path of the high throughput fluid system. The carrier flow inlet and carrier flow outlet are axially misaligned. A stem is movably disposed in the body and in fluid communication with the sample passageway. The stem is moveable between first and second positions. The stem has a fluid bypass fluidly interconnecting the carrier flow inlet and outlet when the stem is in the first position to allow a selected carrier fluid to flow through the valve body to, as an example, a mass spectrometer or other analyzer.