Immunopotentiating formulations for vaccinal use

The present invention is related to the field of medicine, particularly to the development of new formulations for immunological potentiation allowing the increase of the amount and quality of the immune response to vaccine antigens. The present invention is related to the field of medicine, particu...

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Hauptverfasser: Aguilar Rubido, Julio Cesar, Muzio Gonzalez, Verena Lucila, Leal Angulo, Maria de Jesus, Guillen Nieto, Gerardo Enrique, Penton Arias, Eduardo, Veliz Rios, Gloria, Pichardo Diaz, Dagmara, Herrera Buch, Antonieta, Iglesias Perez, Enrique, Cruz Ricondo, Luis Javier, Carmenate Portilla, Tania, Mesa Pardillo, Cirse, Hechavarria Gay, Maydel, Diaz Martinez, Maylin, Madrazo Piñol, Juan Joel
Format: Patent
Sprache:eng
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Zusammenfassung:The present invention is related to the field of medicine, particularly to the development of new formulations for immunological potentiation allowing the increase of the amount and quality of the immune response to vaccine antigens. The present invention is related to the field of medicine, particularly to the use of new adjuvant formulations with vaccine antigens. The technical objective pursued with this invention is, precisely, the development of formulations that are able to increase and/or modulate the immune response of the organism to vaccine antigens in the serum and the mucous lining. With this aim, a formulation was developed that contained as the main components the surface antigen of the hepatitis B virus and the acemannan in adequate proportions. As an extension of this result, formulations were developed in which a) HBsAg was used as the homologous or heterologous antigen carrier b) delivery systems of particulated antigens and c) soluble antigens, combined with the acemannan in specific proportions. The formulations of this invention are applicable in the pharmaceutical industry as vaccine formulations for human and veterinary use.