Sample collection apparatus and method for multiple channel high throughput purification

The present invention is directed to apparatus and methods for use with, as an example, sample purification, and more particularly, to collection apparatus and methods for use with, as an example, high throughput purification of samples from a chemical library. A fraction collection assembly having a frame and a dispensing head movably connected to the frame for movement about three axes. The dispensing head has a dispensing tube that receives and dispenses the sample portion. The dispensing head is movable between a dispensing position, a rinse position, and a pickup position. A receiving container with a receiving well is positioned to receive the sample portion of the selected sample dispensed from the dispensing tube when the dispensing head is in the dispensing position. The receiving well has a 1-to-1 corresponding position to the well from which the sample is originally taken from the supplying container. The rinse station is connected to the frame and positioned to removably receive the dispensing tube when the dispensing head is in the rinse position. A pickup station is provided adjacent to an expansion chamber distribution assembly to retain the expansion chambers in a selected position to be picked up by the dispensing head when in the pick up position prior to distribution of the sample into the receiving container.