Crystals and structures of spleen tyrosine kinase SYKKD

Crystals and structures of spleen tyrosine kinase SYKKD

The present invention provides machine readable media embedded with the three-dimensional molecular structure coordinates of SYKKD and subsets thereof, including binding pockets, methods of using the structure to identify and design affecters, including inhibitors and activator, mutants of SYKKD, an...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Atwell, Shane, Hendle, Jorg, Buchanan, Sean, Feil, Ingeborg, Russell, Marijane, Badger, John, Tomimoto, Masaki, Sauder, Michael
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The present invention provides machine readable media embedded with the three-dimensional molecular structure coordinates of SYKKD and subsets thereof, including binding pockets, methods of using the structure to identify and design affecters, including inhibitors and activator, mutants of SYKKD, and compounds and compositions that affect SYK activity.