Nuclear factors associated with transcriptional regulation

Nuclear factors associated with transcriptional regulation

Constitutive and tissue-specific protein factors which bind to transcriptional regulatory elements of Ig genes (promoter and enhancer) are described. The factors were identified and isolated by an improved assay for protein-DNA binding. Genes encoding factors which positively regulate transcription...

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Bibliographische Detailangaben
Hauptverfasser: Baltimore, David, Sen, Ranjan, Sharp, Phillip, Singh, Harinder, Staudt, Louis, LeBowitz, Jonathan, Baldwin, Albert, Clerc, Roger, Corcoran, Lynn, Baeuerle, Patrick, Lenardo, Michael, Fan, Chen-Ming, Maniatis, Thomas
Format: Patent
Sprache:eng
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Zusammenfassung:Constitutive and tissue-specific protein factors which bind to transcriptional regulatory elements of Ig genes (promoter and enhancer) are described. The factors were identified and isolated by an improved assay for protein-DNA binding. Genes encoding factors which positively regulate transcription can be isolated and employed to enhance transcription of Ig genes. In particular, NF-kB, the gene encoding NF-kB, IkB and the gene encoding IkB and uses therefor.