Indolicidin analogs with anti-microbial activity

Indolicidin analogs with anti-microbial activity

The present invention relates to three single tryptophan analogs ILPWKLPLLPLRR-amide (IL4), ILPLKLPWLPLRR-amide (IL8) and ILPLKLPLLPWRR-amide (IL11), of indolicidin, a cationic tridecapeptide amide found in the granules of bovine neutrophils, said analogs having said amino acid only at 4 th , 8 th o...

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Hauptverfasser: Bikshapathy, E, Subbalakshmi, Chilukuri, Sitaram, Narasimhaiah, Nagaraj, Ramakrishnan
Format: Patent
Sprache:eng
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Zusammenfassung:The present invention relates to three single tryptophan analogs ILPWKLPLLPLRR-amide (IL4), ILPLKLPWLPLRR-amide (IL8) and ILPLKLPLLPWRR-amide (IL11), of indolicidin, a cationic tridecapeptide amide found in the granules of bovine neutrophils, said analogs having said amino acid only at 4 th , 8 th or 11 th position from N-terminal, with leucine at its all other conventional positions, said analogs selectively having only anti-microbial activity and no hemolytic activity of Indolicidin, and thereby providing therapeutic options and a method thereof.