Virus-like particles devoid of HPV 16 type-specific antibody epitopes as carriers of peptides for introduction into cells

The present invention relates to a carrier for introduction of substances into cells comprising a modified major capsid protein L1 of human papillomavirus (HPV-L1 protein) devoid of type-specific epitopes causing production of neutralising antibodies. The invention also includes an oligo- or polynuc...

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Bibliographische Detailangaben
Hauptverfasser: Kristensson, Karin, Antonsson, Per, Wallen-Ohman, Marie, Dillner, Joakim, Lando, Peter
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The present invention relates to a carrier for introduction of substances into cells comprising a modified major capsid protein L1 of human papillomavirus (HPV-L1 protein) devoid of type-specific epitopes causing production of neutralising antibodies. The invention also includes an oligo- or polynucleotide coding for said carrier, vaccines comprising said carrier or said oligo- or polynucleotide, as well as methods of using the carrier or the oligo- or polynucleotide in vaccination against viral, bacterial or parasite infections as well as against development of certain cancers. Especially, infections of human papillomavirus and the development of cancer as a consequence of such infections are recognised.