Bioavailable fenofibrate compositions, methods for treating hyperlipidemia and hypercholesterolemia and processes for the preparation of such compositions

Bioavailable fenofibrate compositions, methods for treating hyperlipidemia and hypercholesterolemia and processes for the preparation of such compositions

Pharmaceutical compositions for treating hyperlipidemia or hypercholesterolemia in mammals are described which comprise: 1 (a) fenofibrate   5 to 35 wt. -% (b) a cyclodextrin   4 to 30 wt. -% (c) an alkali metal or 0.1 to 10 wt. -%; and alkaline earth metal docusate and/or alkali metal or alkaline e...

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Hauptverfasser: Femia, Robert, Fishkis, Oscar, Patel, Damodar, Ragunathan, Narayan
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creator Femia, Robert
Fishkis, Oscar
Patel, Damodar
Ragunathan, Narayan
description Pharmaceutical compositions for treating hyperlipidemia or hypercholesterolemia in mammals are described which comprise: 1 (a) fenofibrate   5 to 35 wt. -% (b) a cyclodextrin   4 to 30 wt. -% (c) an alkali metal or 0.1 to 10 wt. -%; and alkaline earth metal docusate and/or alkali metal or alkaline earth metal lauryl sulfate (d) a water-insoluble, wettable   5 to 30 wt. -% inorganic carrier capable of forming a dispersion of the fenofibrate and a pharmaceutically acceptable inert carrier or diluent. A therapeutically effective amount of the compositions are orally administered to mammals to treat hyperlipidemia or hypercholesterolemia.
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title Bioavailable fenofibrate compositions, methods for treating hyperlipidemia and hypercholesterolemia and processes for the preparation of such compositions
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