Bioavailable fenofibrate compositions, methods for treating hyperlipidemia and hypercholesterolemia and processes for the preparation of such compositions

Pharmaceutical compositions for treating hyperlipidemia or hypercholesterolemia in mammals are described which comprise: 1 (a) fenofibrate   5 to 35 wt. -% (b) a cyclodextrin   4 to 30 wt. -% (c) an alkali metal or 0.1 to 10 wt. -%; and alkaline earth metal docusate and/or alkali metal or alkaline e...

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Bibliographische Detailangaben
Hauptverfasser: Femia, Robert, Fishkis, Oscar, Patel, Damodar, Ragunathan, Narayan
Format: Patent
Sprache:eng
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Zusammenfassung:Pharmaceutical compositions for treating hyperlipidemia or hypercholesterolemia in mammals are described which comprise: 1 (a) fenofibrate   5 to 35 wt. -% (b) a cyclodextrin   4 to 30 wt. -% (c) an alkali metal or 0.1 to 10 wt. -%; and alkaline earth metal docusate and/or alkali metal or alkaline earth metal lauryl sulfate (d) a water-insoluble, wettable   5 to 30 wt. -% inorganic carrier capable of forming a dispersion of the fenofibrate and a pharmaceutically acceptable inert carrier or diluent. A therapeutically effective amount of the compositions are orally administered to mammals to treat hyperlipidemia or hypercholesterolemia.